The effects of aging over the dental pulp: A review
DOI:
https://doi.org/10.36958/sep.v6i1.163Keywords:
aging, dental pulp, old age, pulpal changes, pulp cellsAbstract
Currently the interest in the preservation of dental pieces has been increasing, which is why the demand for endodontic treatments in aged pieces has increased. OBJECTIVE: This review seeks to describe the changes that the aging process entails at the level of odontoblasts, pulpal stem cells, nervous tissue, and vascular tissue of the dental pulp. METHOD: For the preparation of this bibliographical review the search engines PubMed and Research4Life were used to gain access to textbooks and scientific articles related to the subject. RESULTS: The articles obtained in the search were analyzed at the title and abstract level prior to being included in the review. Giving rise to a total of 29 references. CONCLUSION: The changes in the dental organ, produced by aging, can generate changes at a cellular level, irrigation, innervation and can even reduce the volume of the pulp chamber. These changes can cause an alteration in the response and repair capacity of the pulp organ, for which they must be considered by the clinician prior to carrying out an endodontic diagnosis or procedure in pieces with aged dental pulps.
Downloads
References
AAE. (2021). AAE Position Statement on Vital Pulp Therapy. Journal of Endodontics, 47(9), 1340–1344. doi:10.1016/j.joen.2021.07.015 DOI: https://doi.org/10.1016/j.joen.2021.07.015
Alvarado, A. &. (2014). Análisis del concepto de envejecimiento. Gerokomos, 25(2), 57–62. doi:10.4321/s1134-928x2014000200002 DOI: https://doi.org/10.4321/S1134-928X2014000200002
Bernick, S. (1967). Age Changes in the Blood Supply to Human Teeth. Journal of Dental Research, 46(3), 544–550. doi:10.1177/00220345670460031501 DOI: https://doi.org/10.1177/00220345670460031501
Bernick, S. (1967). Effect of Aging On the Nerve Supply To Human Teeth. Journal of Dental Research, 46(4), 694–699. doi:10.1177/00220345670460041101 DOI: https://doi.org/10.1177/00220345670460041101
Carvalho, T. S. (2017). Age-related morphological, histological and functional changes in teeth. Journal of Oral Rehabilitation, 44(4), 291–298. doi:10.1111/joor.12474 DOI: https://doi.org/10.1111/joor.12474
Couve, E. L. (2017). Schwann Cell Phenotype Changes in Aging Human Dental Pulp. Journal of Dental Research, 97 (3), 347–355. doi:10.1177/0022034517733967 DOI: https://doi.org/10.1177/0022034517733967
Daud, S. N. (2014). Changes in cell density and morphology of selected cells of the ageing human dental pulp. Gerodontology, 33(3), 315–321. doi:10.1111/ger.12154 DOI: https://doi.org/10.1111/ger.12154
Dzeletovic, B. S. (2020). Linear and nonlinear analysis of dental pulp blood flow oscillations in ageing. International Endodontic Journal. doi:doi:10.1111/iej.13306 DOI: https://doi.org/10.1111/iej.13306
Farac, R. V. (2012). Pulp sensibility test in elderly patients. . Gerodontology, 29(2), 135–139. doi:10.1111/j.1741-2358.2012.00623.x DOI: https://doi.org/10.1111/j.1741-2358.2012.00623.x
Fried, K. &. (2014). Dental pulp innervation. The Dental pulp: Biology, pathology and regenerative therapies, 75-95. doi:doi.org/10.1007/978-3-642-55160-4_6 DOI: https://doi.org/10.1007/978-3-642-55160-4_6
Hargreaves, K. &. (2011). Cohen Vías de la Pulpa. Barcelona: Elsevier.
Hargreaves, K. G. (2012). Seltzer and Bender’s Dental Pulp 2 ed. . Georgia: Quintessence .
Hayflick L, M. P. (1961). The serial cultivation of human diploid cell strains. Exp Cell Res, 25, 585–621. DOI: https://doi.org/10.1016/0014-4827(61)90192-6
Hayflick, L. (2007). Biological aging is no longer an unsolved problem. Ann N Y Acad Sci, 1100, 1–13. DOI: https://doi.org/10.1196/annals.1395.001
Iezzi, I. P.-B. (2019). The effects of ageing on dental pulp stem cells, the tooth longevity elixir. European Cells and Materials(37), 175–185. doi:10.22203/ecm.v037a11 DOI: https://doi.org/10.22203/eCM.v037a11
Jafarzadeh, H. &. (2010). Review of pulp sensibility tests. Part I: general information and thermal tests. International Endodontic Journal, 43(9), 738–762. doi:10.1111/j.1365-2591.2010.01754.x DOI: https://doi.org/10.1111/j.1365-2591.2010.01754.x
Jespersen, J. J. (2014). Evaluation of Dental Pulp Sensibility Tests in a Clinical Setting. Journal of Endodontics, 40(3), 351–354. doi:10.1016/j.joen.2013.11.009 DOI: https://doi.org/10.1016/j.joen.2013.11.009
Johnstone, M. &. (2015). Endodontics and the ageing patient. Australian Dental Journal(60), 20-27. doi:10.1111/adj.12281 DOI: https://doi.org/10.1111/adj.12281
Kregel, K. C. (2007). An integrated view of oxidative stress in aging: basic mechanisms, functional effects, and pathological considerations. American journal of physiology, 292(1), R18-R36. DOI: https://doi.org/10.1152/ajpregu.00327.2006
Lee, Y.-H. K.-E.-J.-K.-H.-K. (2013). Aging of In Vitro Pulp Illustrates Change of Inflammation and Dentinogenesis. Journal of Endodontics,, 39(3), 340–345. doi:10.1016/j.joen.2012.10.031 DOI: https://doi.org/10.1016/j.joen.2012.10.031
Maeda, H. (2021). Aging and Senescence of Dental Pulp and Hard Tissues of the Tooth. Frontiers in Cell and Developmental Biology, 8:605996. doi:10.3389/fcell.2020.605996 DOI: https://doi.org/10.3389/fcell.2020.605996
Mahdee, A. E. (2018). Evidence for changing nerve growth factor signalling mechanisms during development, maturation and ageing in the rat molar pulp. International Endodontic Journal. doi:10.1111/iej.12997 DOI: https://doi.org/10.1111/iej.12997
Mccabe, P. S. (2011). Pulp canal obliteration: an endodontic diagnosis and treatment challenge. International endodontic journal,, 45(2), 177–197. doi:10.1111/j.1365-2591.2011.01963.x DOI: https://doi.org/10.1111/j.1365-2591.2011.01963.x
Mitsiadis, T. A.-R. (2015). Stem cell-based approaches in dentistry. . European cells & materials, 30, 248–257. doi:10.22203/ecm.v030a17 DOI: https://doi.org/10.22203/eCM.v030a17
Morse, D. R. (1991). Age-related changes of the dental pulp complex and their relationship to systemic aging. Oral Surgery, Oral Medicine, Oral Pathology, , 72(6), 721–745. doi:10.1016/0030-4220(91)90019-9 DOI: https://doi.org/10.1016/0030-4220(91)90019-9
Murray, P. E. (2002). Age-related odontometric changes of human teeth. . Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 93(4), 474–482. doi:10.1067/moe.2002.1209
Ning, T. S. (2019). Aging affects the proliferation and mineralization of rat dental pulp stem cells under inflammatory conditions. International Endodontic Journal. doi:10.1111/iej.13205 DOI: https://doi.org/10.1111/iej.13205
Özgül, R. Ö. (2021). Age-related changes in the immunomodulatory effects of human dental pulp derived mesenchymal stem cells on the CD4+ T cell subsets. Cytokine, 138, 155367. doi:10.1016/j.cyto.2020.155367 DOI: https://doi.org/10.1016/j.cyto.2020.155367
Timme, M. B. (2021). Age dependent decrease in dental pulp cavity volume as a feature. International Journal of Legal Medicine. doi:https://doi.org/10.1007/s00414-021-02603-1 DOI: https://doi.org/10.1007/s00414-021-02603-1
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Carlos Javier Avila Utrera
This work is licensed under a Creative Commons Attribution 4.0 International License.
The authors who publish in this journal accept the following conditions:
- The authors retain the copyright and assign to the journal the right of the first publication, with the work registered with the Creative Commons 4.0 attribution license, which allows third parties to use what is published as long as they mention the authorship of the work already the first publication in this magazine.
- Authors may make other independent and additional contractual agreements for the non-exclusive distribution of the version of the article published in this journal (eg, include it in an institutional repository or publish it in a book) provided that they clearly indicate that the work it was first published in this magazine.
- Authors are allowed and encouraged to share their work online (for example: in institutional repositories or personal web pages) before and during the manuscript submission process, as it can lead to productive exchanges, more and more quick citation of published work (see The Effect of Open Access).
