Correlation between Anti-Müllerian Hormone and Antral Follicle Count as Markers of Ovarian Reserve in Women of Reproductive Age
DOI:
https://doi.org/10.36958/sep.v8i1.324Keywords:
hormona antimülleriana, folículos antrales, reserva ováricaAbstract
OBJECTIVE: to analyze the relationship between serum anti-Müllerian hormone (AMH) levels and antral follicle count (AFC) as complementary indicators of ovarian reserve in fertile women treated at Pedro de Bethancourt Hospital during 2023. METHOD: this cross-sectional descriptive correlational study included 95 women aged 18 to 35 years with regular menstrual cycles, both ovaries present, and no history of chemotherapy, radiotherapy, or prior ovarian surgeries. Serum AMH levels were measured, and transvaginal ultrasound was performed between days 1 and 3 of the menstrual cycle to count antral follicles. For the purpose of this study, AMH was classified as low (<1.37 ng/ml) or normal (≥1.38 ng/ml). AFC was categorized as normal ovarian reserve (≥10 follicles) or high ovarian reserve (>11 follicles). Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and Youden index were calculated. Spearman’s correlation coefficient (ρ) was used to evaluate the relationship between AMH levels and AFC. RESULTS: a moderate positive correlation was observed between AMH and AFC (r = 0.48, p < 0.01). The AMH presented sensitivity of 80%, an NPV of 81.2%. 83% of patients showed normal AMH with high AFC, which highlights the importance of their joint evaluation. CONCLUSION: in conclusion, AMH significantly correlates with antral follicle count. Its high sensitivity and NPV support its utility as a screening tool for ovarian reserve assessment, particularly when used in conjunction with ultrasound.
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